VitaminD - Identification of genes and their regulatory motifs that are involved in antiproliferative signaling induced by 1,25-dihydroxyvitamin D3 or in the tissue-selective activity of vitamin D analogs.
From 01-01-2006 to 31-12-2009
Description
By the use of elaborate microarray experiments, the present project aims to achieve a better insight in the mechanisms of the antiproliferative activity and of the tissue-selectivity of vitamin D3-analogs. Collaboration between LEGENDO, an expert biological research lab in the vitamin D-field, and ESAT, a well established bioinformatics research group, will allow optimal design of microarray experiments. Subsequent bioinformatical analysis aims to characterize clusters of genes which represent novel signal transduction pathways or cell-biological processes that mediate the antiproliferative effects of 1,25(OH)2D3. Promoters of these genes will be screened for conserved motifs and corresponding transcription factors, involved in 1,25(OH)2D3-signaling, will be identified. Finally, bioinformatics data will be validated in biological cell systems. This close interplay makes up the strength of our collaboration and will increase the quality and scientific value of the microarray studies.Team
- L Verlinden, Co-promoter (External)
- Bart De Moor, Co-promoter
- Mieke Verstuyf, Co-promoter (External)
- R. Bouillon, Promoter (External)
- Kristof Engelen, Team member
- Kathleen Marchal, Team member
Financing
Funding: FWO - Research Foundation - Flanders
Program/Grant Type: FWO Research Grant - FWO Research Grant
Events
2/09/2024:
PhD defense - Martijn Oldenhof
Machine Learning for Advanced Chemical Analysis and Structure Recognition in Drug Discovery
3/09/2024:
Meet the Jury Igor Tetko on Advanced Machine Learning in Drug Discovery
12/09/2024:
Multimodal analysis of cell-free DNA for sensitive cancer detection in low-coverage and low-sample settings
Seminar by Antoine Passemiers
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