endometriosis-proteomics - Noninvasive diagnosis of endometriosis based on plasma proteomics analysis
From 01-01-2013 to 31-12-2013
Description
Endometriosis, defined as the presence of ectopic endometrium outside the uterus, is associated with chronic intrapelvic inflammation. The gold standard for diagnosis of endometriosis is laparoscopic surgery with histological confirmation (Kennedy et al, 2005). The laparoscopic appearance of endometriosis includes superficial peritoneal lesions, pelvic adhesions, ovarian endometriotic cysts and deeply infiltrative disease, classified (ASRM, 1997) as minimal, mild, moderate and severe disease. Vaginal ultrasound is an adequate diagnostic method to detect ovarian endometriotic cysts and, but does not rule out peritoneal endometriosis or endometriosis-associated adhesions (Moore et al., 2002). Due to the underestimation of pelvic pain symptoms, the need for surgical diagnosis, and the lack of a non-invasive test for endometriosis not detectable by ultrasound, the delay between onset of symptoms and diagnosis can be 8-11 years. The measurement of serum CA-125 levels has no value as a diagnostic tool compared to laparoscopy (Kennedy et al., 2005). At present, neither a single biomarker nor a panel of biomarkers measurable in peripheral blood have been validated as a non-invasive test for endometriosis (May et al., 2010).
Team
- Etienne Waelkens, Co-promoter (External)
- Bart De Moor, Co-promoter
- Thomas D'Hooghe, Promoter (External)
- Inge Thijs, Team member
- Dusan Popovic, Team member
Financing
Funding: KU Leuven - Internal Funding KU Leuven
Program/Grant Type: IOF - IOF-mandaten: Postdoctoral Fellowships
Events
2/09/2024:
PhD defense - Martijn Oldenhof
Machine Learning for Advanced Chemical Analysis and Structure Recognition in Drug Discovery
3/09/2024:
Meet the Jury Igor Tetko on Advanced Machine Learning in Drug Discovery
12/09/2024:
Multimodal analysis of cell-free DNA for sensitive cancer detection in low-coverage and low-sample settings
Seminar by Antoine Passemiers
News
STADIUS Alumni Herman Verrelst – new CEO of Biocartis
08 June 2017
Herman Verrelst, the founder of KU Leuven spin-off Cartagenia, who has been working in Silicon Valley, US for the last few years will be returning to Belgium to follow the steps of Rudi Pauwels as CEO of the Belgian diagnostic company, Biocartis.
Supporting healthcare policymaking via machine learning – batteries included!
29 May 2017
STADIUS takes the lead in the data analytics efforts in an ambitious European Project MIDAS.
Marc Claesen gives an interview about his PhD for the magazine of the Faculty of Engineering Sciences "Geniaal"
10 February 2017
Did you know that in Belgium approximately one third of type 2 diabetes patients are unaware of their condition?
Joos Vandewalle is nieuwe voorzitter KVAB
09 October 2016
Op 5 oktober 2016 heeft de Algemene Vergadering van de Academie KVAB Joos Vandewalle verkozen tot voorzitter van de KVAB.