Hercules III - PacBio RS - Sequencing with the PacBio RS system based on our single molecule, real-time (SMRT) technology
From 01-03-2012 to 31-12-2016
Description
The PacBio RS system fills an important gap in the instrumentation that is necessary to address major scientific questions in genomics. The PacBio RS is a third -generation sequencing platform with Single Molecule Real Time technology (SMRT). The sequencer introduces several new features to sequencing that are complementary with the current (second generation) sequencers that are available at the Genomics Core in Leuven and in other facilities in Flanders: It is the first instrument to detect DNA in real time. Moreover, no amplification step is required during sample preparation, because every sequence read derives from a single DNA molecule (single molecule sequencing). A further benefit is the long read length of more than 1,000 base pairs, which can currently only be achieved with conventional Sanger-based sequencing, but not by other high-throughput instruments. These long reads lead to a new quality in the sequence data for many applications. The system will enable direct RNA and epigenome sequencing. Finally, the application domains of PacBio RS go well beyond sequencing as the system has the capacity to measure the kinetics of DNA-protein interactions.
Team
- Diether Lambrechts, Co-promoter (External)
- Stein Aerts, Co-promoter (External)
- Yves Moreau, Co-promoter
- Jan Cools, Co-promoter (External)
- Joris Vermeesch, Promoter (External)
Financing
Funding: Vlaamse overheid - Vlaamse overheid
Program/Grant Type: Hercules - Zware en middlezware onderzoeksinfrastructuur
Events
2/09/2024:
PhD defense - Martijn Oldenhof
Machine Learning for Advanced Chemical Analysis and Structure Recognition in Drug Discovery
3/09/2024:
Meet the Jury Igor Tetko on Advanced Machine Learning in Drug Discovery
12/09/2024:
Multimodal analysis of cell-free DNA for sensitive cancer detection in low-coverage and low-sample settings
Seminar by Antoine Passemiers
News
STADIUS Alumni Herman Verrelst – new CEO of Biocartis
08 June 2017
Herman Verrelst, the founder of KU Leuven spin-off Cartagenia, who has been working in Silicon Valley, US for the last few years will be returning to Belgium to follow the steps of Rudi Pauwels as CEO of the Belgian diagnostic company, Biocartis.
Supporting healthcare policymaking via machine learning – batteries included!
29 May 2017
STADIUS takes the lead in the data analytics efforts in an ambitious European Project MIDAS.
Marc Claesen gives an interview about his PhD for the magazine of the Faculty of Engineering Sciences "Geniaal"
10 February 2017
Did you know that in Belgium approximately one third of type 2 diabetes patients are unaware of their condition?
Joos Vandewalle is nieuwe voorzitter KVAB
09 October 2016
Op 5 oktober 2016 heeft de Algemene Vergadering van de Academie KVAB Joos Vandewalle verkozen tot voorzitter van de KVAB.