IOTA 3 Ovarian tumour characterisation - Multicentre prospective assessment study on the pre-operative characterisation of ovarian tumours based on predictive computer models

From 01-06-2008 to 31-05-2012

Description

The aim is to prospectively test and implement previously developed mathematical algorithms for the pre-operative classification of adnexal masses. IOTA phase 3 is a prospective multicentre study. The information obtained will be used to define the optimal management of patients presenting with adnexal tumours. More than 2,000 patients, with at least one adnexal mass, will be recruited and studied within 3 months before investigative surgery. Medical and family histories will be recorded. Transvaginal ultrasonography with colour Doppler imaging will be used to derive indices of tumour form and blood flow. A sample of peripheral venous blood will be taken for the analyses of serum CA-125 and other tumour markers and in certain centres additional blood will be taken and stored appropriately to test proteomic pattern analysis. Findings at surgery and the histological classification of excised tissues as malignant or benign (and by cell type) will be used as outcome measures. Conventional and novel algorithms (including proteomic patterns), which can be used to effectively classify difficult adnexal masses will be tested prospectively in centres throughout the world.
Dirk Timmerman (spokesperson)

Team

• Bart De Moor, Co-promoter
• Sabine Van Huffel, Co-promoter
• Olivier Gevaert, Team member
• Vanya Van Belle, Team member
• Anneleen Daemen, Team member

Financing

Funding: IWT - Agentschap voor Innovatie door Wetenschap en Technologie 

Program/Grant Type: IWT TBM - VLAIO TBM Projects Applied Biomedical Research with a Primary Social finality