SymBioSys4 - SymBioSys: Computationally mapping genomic heterogeneity from long read sequencing data
From 01-10-2022 to 30-09-2026
Description
Cells are basic units of life and, not surprisingly, single-cell analyses are revolutionizing our understanding of the extent, nature, and biology of cellular diversity throughout the lifetime of an organism, in health and disease. Recent advances in long-read sequencing now allow combining the advantages of single-molecule long reads with the revolution of single-cell multi-omics. This offers exciting opportunities to answer a plethora of questions. Still, the tools for long-read genome-wide analyses are in their infancy. With this project, we will address a series of computational challenges and develop algorithms and tools in four key areas: (1) Multi-cell long-read ‘omics’ (2) single-molecule long-read multi-omics, (3) single-cell long-read mult-omics and (4) artificial intelligence approaches for mechanistic/functional (pathway, gene regulatory network) interpretation. These bioinformatic frameworks will be applied to four relevant use cases for which the partners in this project have ample experience, have already generated long-read and single-cell data for, and have matched funds to generate additional data sets and follow up new discoveries with in vitro and in vivo validation. These research areas include embryo development, neurodevelopmental disorders, cellular heterogeneity in cancer in treatment naive and drug exposed conditions, and the aging brain.
Team
- Yves Moreau, Co-promoter
- Thierry Voet, Co-promoter (External)
- Diether Lambrechts, Co-promoter (External)
- Stein Aerts, Co-promoter (External)
- Joris Vermeesch, Coordinator (External)
Financing
Funding: KU Leuven - Internal Funding KU Leuven
Program/Grant Type: C1 - KU Leuven Category 1 Funding
Events
2/09/2024:
PhD defense - Martijn Oldenhof
Machine Learning for Advanced Chemical Analysis and Structure Recognition in Drug Discovery
3/09/2024:
Meet the Jury Igor Tetko on Advanced Machine Learning in Drug Discovery
12/09/2024:
Multimodal analysis of cell-free DNA for sensitive cancer detection in low-coverage and low-sample settings
Seminar by Antoine Passemiers
News
STADIUS Alumni Herman Verrelst – new CEO of Biocartis
08 June 2017
Herman Verrelst, the founder of KU Leuven spin-off Cartagenia, who has been working in Silicon Valley, US for the last few years will be returning to Belgium to follow the steps of Rudi Pauwels as CEO of the Belgian diagnostic company, Biocartis.
Supporting healthcare policymaking via machine learning – batteries included!
29 May 2017
STADIUS takes the lead in the data analytics efforts in an ambitious European Project MIDAS.
Marc Claesen gives an interview about his PhD for the magazine of the Faculty of Engineering Sciences "Geniaal"
10 February 2017
Did you know that in Belgium approximately one third of type 2 diabetes patients are unaware of their condition?
Joos Vandewalle is nieuwe voorzitter KVAB
09 October 2016
Op 5 oktober 2016 heeft de Algemene Vergadering van de Academie KVAB Joos Vandewalle verkozen tot voorzitter van de KVAB.