CARDIOCONTROL - "Alterations in autonomic cardiovascular control induced at partial G forces CardioControl"
From 01-01-2011 to 31-12-2013
Description
Background.
Cardiovascular
control mechanisms by the autonomic nervous system (ANS)have been studied as a
function of level of gravity during parabolic flights. However, untilnow, no
intermediary G values could be obtained. In view of existing results, it can behypothesized
that autonomic cardiovascular control will act gradually at partial G-forces,
i.e. alinear relationship between different cardiovascular parameters and G-forces
can be expected.The parabolic flights at Mars/Moon level of gravity give a
unique opportunity to test thishypothesis.
Aims of the study: 1) to
evaluate the effects of partial G transition (Mars and Moon G forces)on
cardiovascular parameters; 2) to assess parameters of cardiac function during
different Gphasesto appraise a possible relationship between the former and the
latter; 3) to investigateautonomic cardiovascular control at different
G-levels; 4) to compare elements of cardiacfunction at G-Mars, with
physiological measurements obtained during a confinement study.
Methods. The experimental protocol includes noninvasive methods: 1) ECG recording toassess heart rate variability (HRV) and spectral HRV analysis to assess ANS during thedifferent phases of gravity; 2) finger-cuff blood pressure to obtain blood pressure variability(BPV), combination of the former and the latter provides access to the baroreflex; 3)respiration to assess vagal modulation. Time-frequency analysis will be used to assessdynamic changes and instantaneous frequency. Moreover (non)linear signal analysisalgorithms will be used to evaluate the regularity and synchronization of cardiorespiratorycoupling.
Team
- Sabine Van Huffel, Promoter
- Steven Vandeput, Team member
Financing
Funding: -
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