BioFrame - A Bioinformatics Framework for Top-Down Systems Biology
From 01-04-2007 to 31-03-2011
Description
Bioframe is a project that targets the conception of a bio-informatics platform for Systems Biology, with in its core tools for building models through data-integration. Systems biology is the study of an organism, viewed as an integrated and interacting network of genes, proteins and biochemical reactions. This goal can primarily be achieved through the interpretation of large amounts of high-throughput transcriptomics, proteomics, and metabolomics data. As this type of data grasps the intertwined mechanics of the cell at different levels, inferring knowledge from their combination allows leveraging the building of mechanistic models to attain the global goal of Systems Biology. Within this setting, Bioframe’s main focus is algorithmic, since this is the hart of the integrated modeling approach, and exactly where the main limitation exists today. Bioframe seeks to propose beyond state-of-the-art algorithms for knowledge inference, model building and model querying, as well as computational support for the design of data integration experiments.Team
- Kathleen Marchal, Promoter
Financing
Funding: IWT - Agentschap voor Innovatie door Wetenschap en Technologie
Program/Grant Type: IWT SBO - IWT Projects Strategic Basic Research
Events
2/09/2024:
PhD defense - Martijn Oldenhof
Machine Learning for Advanced Chemical Analysis and Structure Recognition in Drug Discovery
3/09/2024:
Meet the Jury Igor Tetko on Advanced Machine Learning in Drug Discovery
12/09/2024:
Multimodal analysis of cell-free DNA for sensitive cancer detection in low-coverage and low-sample settings
Seminar by Antoine Passemiers
News
STADIUS Alumni Herman Verrelst – new CEO of Biocartis
08 June 2017
Herman Verrelst, the founder of KU Leuven spin-off Cartagenia, who has been working in Silicon Valley, US for the last few years will be returning to Belgium to follow the steps of Rudi Pauwels as CEO of the Belgian diagnostic company, Biocartis.
Supporting healthcare policymaking via machine learning – batteries included!
29 May 2017
STADIUS takes the lead in the data analytics efforts in an ambitious European Project MIDAS.
Marc Claesen gives an interview about his PhD for the magazine of the Faculty of Engineering Sciences "Geniaal"
10 February 2017
Did you know that in Belgium approximately one third of type 2 diabetes patients are unaware of their condition?
Joos Vandewalle is nieuwe voorzitter KVAB
09 October 2016
Op 5 oktober 2016 heeft de Algemene Vergadering van de Academie KVAB Joos Vandewalle verkozen tot voorzitter van de KVAB.