PROSTAATCARCINOOM: “Implementation of functional imaging and molecular diagnostics for patienttailored treatment of prostate cancer”
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Financing: Other Funding Agencies (OTHER)
Project reference Nr.: Onkelinckx/3M090645 Start: 2009-09-15 End: 2010-12-31
Description: translationeel onderzoeksproject over prostaatcarcinoom in kader van het
kankerplan
With more than 9000 new cases annually, prostate cancer (PCa) accounts for approximately 30% of all cancer cases in Belgium and is the second leading cause of cancer-related death in men. Treatment options of PCa and the success rate of intervention largely depend on the stage of the disease at the time of diagnosis. Since the implementation of routine PSA testing for detection of PCa, 70-80% of PCa patients present with early stage tumours. Many of the diagnosed tumours however, are latent and clinically irrelevant thus presenting a risk of overtreatment and therefore a tremendous clinical dilemma as no effective predictive tests for disease progression are available. On the other hand, the rate of biochemical failure is significant notwithstanding locally aggressive therapy and a substantial number of patients will develop clinical metastatic disease or already present with occult (distant) metastases at the time of staging. Both situations emphasize the need for reliable criteria for treatment decision. Nowadays, treatment decision of PCa is largely based on the histopathological TNM (tumour, node, metastasis) system. The histological differentiation of the primary tumour (Gleason scoring system) is the dominant prognostic factor for prediction of the disease outcome, independently of stage and applied therapy. However, both systems provide at best an ad hoc picture of the tumour. Progress in methodologies with the potential to provide a better knowledge of the tumour characteristics, to improve the preoperative TNM staging or to predict therapy response will undoubtedly aid in the selection of more appropriate primary and/or adjuvant treatment options. Recent advances in molecular cancer research and more specifically in cancer imaging and the molecular understanding of cancer progression hold significant promise in this respect and have the power to revolutionize the ways that prostate cancer is diagnosed and treated. Aim: The aim of this project is to translate novel molecular findings on PCa biology into clinical practice by implementing functional imaging techniques (non-invasive) and evaluating novel molecular diagnostic tools (invasive) with the ultimate goal to better predict prognosis and therapeutic responses for PCa patients. Ultimately, this will improve the selection of the optimal treatment for specific patient groups, enabling a more patient-tailored treatment. Moreover, this will lead to reduced overtreatment and thereby avoidance of high costs and possible treatment-related side-effects.
SMC people involved in the project:
- Raymond Oyen (Co-promoter)
- Bart De Moor (Co-promoter)
- Aleyde Van Eynde (Co-promoter)
- Hendrik Van Poppel (Co-promoter)
- Mathieu Bollen (Co-promoter)
- Christophe Deroose (Co-promoter)
- Karin Haustermans (Co-promoter)
- Steven Joniau (Co-promoter)
- Evelyne Lerut (Co-promoter)
- Johannes Swinnen (Promoter)
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Contents updated from database. Copyright 2006 SMC