Congenital heart defects (CHD) are the most frequent form of major birth defects in newborns affecting close to 1% of newborn babies (8 per 1,000). These defects can involve the walls of the heart, the valves of the heart or the arteries and veins near the heart. When confronted with a specific type of CHD, the question rises which genes have already been implicated. Therefore, this Wiki offers a continuously updated overview of all genes implicated in human congenital heart defects, syndromic or not, with their respective phenotype. The congenital heart defects represented in the Wiki, were obtained from the shortlist of the Association for European Pediatric Cardiology (AEPC) .