Endeavour

Candidate genes prioritization through genomic data fusion

You are here on the web client version of Endeavour. For an introduction, latest news, academic or commercial use, contact info, mailing list, please refer to the Endeavour project main page.

How to cite

ENDEAVOUR update: a web resource for gene prioritization in multiple species. Tranchevent L., Barriot R., Yu S., Van Vooren S., Van Loo P., Coessens B., Aerts S., De Moor B., Moreau Y. Nucleic Acids Research, Web Server issue, vol. 36, no. 1, Jun. 2008, pp. 377-384. Abstract
Gene prioritization through genomic data fusion. Aerts S., Lambrechts D., Maity S., Van Loo P., Coessens B., De Smet F., Tranchevent L-C., De Moor B., Marynen P., Hassan B., Carmeliet P. & Moreau Y. Nature Biotechnology. [2006 May;24(5):537-544. PMID: 16680138] Abstract

Prioritize candidate genes

A manual is available here. If this is your first visit, you may try out some examples:

YPEL1 taken from our Nature biotech. paper on DiGeorge syndrome candidate genes.
KCNJ5 taken from the Elbers et al review on obesity and diabetes.
DFNB31 based on the Ebermann et al paper describing the discovery of a novel Usher gene.

Clicking on the gene name (YPEL1, KCNJ5 or DFNB31) will cause the training and the candidate genes to be loaded in the following wizard; this will also select the most appropriate data sources. Then you should go over the different steps ('Next' button, enabled once the training and candidate genes are loaded) to revise the settings and launch the prioritization.

Prioritize your candidates in 4 steps with the following wizard

1. Species

2. Training genes

3. Data sources used to build models

4. Candidates

Training genes (

0 gene

)

	Gene (Reference ID)	Alias	Description
none yet

Add following genes

Candidate genes to prioritize (

0 gene

)

	Gene (Reference ID)	Alias	Description
none yet

Add following candidates

Full genome

Ready

Console (warnings and errors)

clear

Results