ENDEAVOUR Manual

Stein Aerts,Bert Coessens,Peter Van Loo and Leo Tranchevent

Introduction
ENDEAVOUR is a software application for the computational prioritisation of `test genes', based on a set of `training genes'. The ranking of a test gene is based on its similarity with the training genes, using (currently) the following information sources:

• MEDLINE abstracts and LocusLink textual descriptions
• Gene Ontology annotation
• Interpro protein domains
• BIND protein interactions
• KEGG pathways
• EST-based expression data
• Microarray expression data (also microarray data sets in local mysql databases, see the 'Advanced options' section)
• Transcription factor binding sites (TFBS)
• Cis-regulatory modules (combinations of TFBSs)
• Sequence similarity by BLAST

Click here to view a figure describing the ENDEAVOUR procedure.