[edit] Introduction

[edit] Genes currently associated to CHDs

[edit] Genes having non syndromic CHDs

• ACTC - 1 association(s)
  
  
  
  

    

   ASD within oval fossa (secundum) (Non-syndromic)

• ACVR1 - 1 association(s)
  
  
  
  

    

   AVSD: isolated atrial component (primum ASD) (Non-syndromic)

• ACVR2B - 6 association(s)
  
  
  
  

    

   Double outlet RV (Non-syndromic)
  

    

   Complete transposition of great arteries (IVS) (Non-syndromic)
  

    

   Pulmonary valvar stenosis - congenital (Non-syndromic)
  

    

   Dextrocardia: heart predominantly in R hemithorax (Non-syndromic)
  

    

   Position or morphology of thoraco-abdominal organs abnormal (Non-syndromic)
  

    

   AV and/or VA connections abnormal (Non-syndromic)

• ALDH1A2 - 1 association(s)
  
  
  
  

    

   Tetralogy of Fallot (Non-syndromic)

• ANKRD1 - 1 association(s)
  
  
  
  

    

   Totally anomalous pulmonary venous connection (Non-syndromic)

• CFC1/CRYPTIC - 8 association(s)
  
  
  
  

    

   AVSD: atrial & ventricular components (complete) (Non-syndromic)
  

    

   VSD (Non-syndromic)
  

    

   Double outlet RV (Syndromic)
  

    

   Double outlet RV (Non-syndromic)
  

    

   Tetralogy of Fallot (Non-syndromic)
  

    

   Interrupted aortic arch (Non-syndromic)
  

    

   Complete transposition of great arteries (IVS) (Non-syndromic)
  

    

   ASD (Non-syndromic)

• CITED2 - 2 association(s)
  
  
  
  

    

   VSD (Non-syndromic)
  

    

   ASD (Non-syndromic)

• CRELD1 - 2 association(s)
  
  
  
  

    

   AVSD: atrial & ventricular components (complete) (Non-syndromic)
  

    

   AVSD: isolated atrial component (primum ASD) (Non-syndromic)

• ELN - 11 association(s)
  
  
  
  

    

   Supravalvar pulmonary trunk stenosis (Non-syndromic)
  

    

   Peripheral pulmonary arterial stenoses - at/beyond hilar bifurcation (Non-syndromic)
  

    

   Pulmonary valvar stenosis - congenital (Non-syndromic)
  

    

   Supravalvar aortic stenosis (Non-syndromic)
  

    

   Supravalvar aortic stenosis (Syndromic)
  

    

   Subaortic stenosis (Syndromic)
  

    

   Aortic valvar stenosis - congenital (Syndromic)
  

    

   Peripheral pulmonary arterial stenoses - at/beyond hilar bifurcation (Syndromic)
  

    

   Mitral valvar prolapse (Syndromic)
  

    

   Bicuspid aortic valve (Syndromic)
  

    

   Aortic valvar stenosis - congenital (Non-syndromic)

• FOG2/ZFPM2 - 3 association(s)
  
  
  
  

    

   Tetralogy of Fallot (Non-syndromic)
  

    

   Double outlet RV (Non-syndromic)
  

    

   Tricuspid atresia (Non-syndromic)

• FOXH1 - 2 association(s)
  
  
  
  

    

   Complete transposition of great arteries (IVS) (Non-syndromic)
  

    

   Tetralogy of Fallot (Non-syndromic)

• GATA4 - 6 association(s)
  
  
  
  

    

   ASD (Non-syndromic)
  

    

   Atrioventricular septal defect (Non-syndromic)
  

    

   Pulmonary valvar stenosis - congenital (Non-syndromic)
  

    

   Partially anomalous pulmonary venous connection(s) (Non-syndromic)
  

    

   Tetralogy of Fallot (Non-syndromic)
  

    

   VSD (Non-syndromic)

• GATA6 - 6 association(s)
  
  
  
  

    

   AVSD with ventricular imbalance (Non-syndromic)
  

    

   Common arterial trunk (Non-syndromic)
  

    

   ASD (Non-syndromic)
  

    

   Tetralogy of Fallot (Non-syndromic)
  

    

   Pulmonary valvar stenosis - congenital (Non-syndromic)
  

    

   Patent arterial duct (PDA) (Non-syndromic)

• GDF1 - 5 association(s)
  
  
  
  

    

   Complete transposition of great arteries (IVS) (Non-syndromic)
  

    

   Right isomerism ('asplenia') (Non-syndromic)
  

    

   Double outlet RV (Non-syndromic)
  

    

   AV and/or VA connections abnormal (Non-syndromic)
  

    

   Tetralogy of Fallot (Non-syndromic)

• GJA1 - 2 association(s)
  
  
  
  

    

   ASD (Syndromic)
  

    

   Hypoplastic left heart syndrome (Non-syndromic)

• HAND2 - 1 association(s)
  
  
  
  

    

   Tetralogy of Fallot (Non-syndromic)

• HEY2 - 1 association(s)
  
  
  
  

    

   Tricuspid atresia (Non-syndromic)

• IRX4 - 1 association(s)
  
  
  
  

    

   VSD (Non-syndromic)

• JAG1 - 10 association(s)
  
  
  
  

    

   Tetralogy of Fallot (Non-syndromic)
  

    

   VSD (Syndromic)
  

    

   Peripheral pulmonary arterial stenoses - at/beyond hilar bifurcation (Non-syndromic)
  

    

   Peripheral pulmonary arterial stenoses - at/beyond hilar bifurcation (Syndromic)
  

    

   Pulmonary atresia + VSD (including Fallot type) (Syndromic)
  

    

   Pulmonary valvar stenosis - congenital (Syndromic)
  

    

   Tetralogy of Fallot (Syndromic)
  

    

   Aortic coarctation (Syndromic)
  

    

   Aortic stenosis (Syndromic)
  

    

   Pulmonary atresia + intact ventricular septum (Syndromic)

• LEFTY2 - 7 association(s)
  
  
  
  

    

   Aortic coarctation (Non-syndromic)
  

    

   Position or morphology of thoraco-abdominal organs abnormal (Non-syndromic)
  

    

   AVSD: atrial & ventricular components (complete) (Non-syndromic)
  

    

   Left SVC persisting to coronary sinus to right-sided atrium (Non-syndromic)
  

    

   Interrupted aortic arch (Non-syndromic)
  

    

   Inferior caval vein (IVC) abnormality (Non-syndromic)
  

    

   Congenitally corrected transposition of great arteries (Non-syndromic)

• MAP3K7IP2 - 1 association(s)
  
  
  
  

    

   LV outflow tract obstruction (Non-syndromic)

• MYH11 - 2 association(s)
  
  
  
  

    

   Aortic sinus of Valsalva aneurysm (Non-syndromic)
  

    

   Patent arterial duct (PDA) (Non-syndromic)

• MYH6 - 5 association(s)
  
  
  
  

    

   Aortic valvar stenosis - congenital (Non-syndromic)
  

    

   Tricuspid atresia (Non-syndromic)
  

    

   ASD within oval fossa (secundum) (Non-syndromic)
  

    

   Complete transposition of great arteries (IVS) (Non-syndromic)
  

    

   Patent foramen ovale (PFO) (Non-syndromic)

• MYH7 - 2 association(s)
  
  
  
  

    

   Ebstein's malformation of tricuspid valve (Non-syndromic)
  

    

   ASD (Non-syndromic)

• NKX2-5/NKX2.5 - 11 association(s)
  
  
  
  

    

   Aortic coarctation (Non-syndromic)
  

    

   Interrupted aortic arch (Non-syndromic)
  

    

   Double outlet RV (Non-syndromic)
  

    

   Sinus venosus ASD (Non-syndromic)
  

    

   Complete transposition of great arteries (IVS) (Non-syndromic)
  

    

   Common arterial trunk (Non-syndromic)
  

    

   Hypoplastic left heart syndrome (Non-syndromic)
  

    

   ASD (Non-syndromic)
  

    

   VSD (Non-syndromic)
  

    

   Tetralogy of Fallot (Non-syndromic)
  

    

   Multiple VSDs (Non-syndromic)

• NKX2-6 - 1 association(s)
  
  
  
  

    

   Common arterial trunk (Non-syndromic)

• NODAL - 13 association(s)
  
  
  
  

    

   Position or morphology of thoraco-abdominal organs abnormal (Non-syndromic)
  

    

   Ventricular imbalance: dominant LV + hypoplastic RV (Non-syndromic)
  

    

   Pulmonary atresia (Non-syndromic)
  

    

   Complete transposition of great arteries (IVS) (Non-syndromic)
  

    

   Tetralogy of Fallot (Non-syndromic)
  

    

   Double outlet RV (Non-syndromic)
  

    

   Dextrocardia: heart predominantly in R hemithorax (Non-syndromic)
  

    

   Atrioventricular septal defect (Non-syndromic)
  

    

   Left SVC persisting to coronary sinus to right-sided atrium (Non-syndromic)
  

    

   Inferior caval vein (IVC) abnormality (Non-syndromic)
  

    

   Totally anomalous pulmonary venous connection (Non-syndromic)
  

    

   Ventricular imbalance: dominant RV + hypoplastic LV (Non-syndromic)
  

    

   AV and/or VA connections abnormal (Non-syndromic)

• NOTCH1 - 4 association(s)
  
  
  
  

    

   Aortic coarctation (Non-syndromic)
  

    

   Hypoplastic left heart syndrome (Non-syndromic)
  

    

   Bicuspid aortic valve (Non-syndromic)
  

    

   Aortic valvar stenosis - congenital (Non-syndromic)

• PDGFRA - 1 association(s)
  
  
  
  

    

   Totally anomalous pulmonary venous connection (Non-syndromic)

• TBX1 - 4 association(s)
  
  
  
  

    

   Pulmonary valvar stenosis - congenital (Syndromic)
  

    

   Tetralogy of Fallot (Syndromic)
  

    

   Interrupted aortic arch (Syndromic)
  

    

   R aortic arch (Non-syndromic)

• TBX20 - 3 association(s)
  
  
  
  

    

   Mitral valvar stenosis - congenital (Non-syndromic)
  

    

   ASD (Non-syndromic)
  

    

   VSD (Non-syndromic)

• TDGF1 - 2 association(s)
  
  
  
  

    

   Tetralogy of Fallot (Non-syndromic)
  

    

   VSD (Non-syndromic)

• TFAP2B - 5 association(s)
  
  
  
  

    

   Bicuspid aortic valve (Syndromic)
  

    

   Patent arterial duct (PDA) (Syndromic)
  

    

   Patent arterial duct (PDA) (Non-syndromic)
  

    

   VSD (Syndromic)
  

    

   Aortic coarctation (Syndromic)

• THRAP2 - 1 association(s)
  
  
  
  

    

   Complete transposition of great arteries (IVS) (Non-syndromic)

• VEGF - 1 association(s)
  
  
  
  

    

   Aortic coarctation (Non-syndromic)

• ZIC3 - 12 association(s)
  
  
  
  

    

   Double outlet RV (Non-syndromic)
  

    

   Multiple VSDs (Non-syndromic)
  

    

   VSD (Non-syndromic)
  

    

   Complete transposition of great arteries (IVS) (Non-syndromic)
  

    

   Dextrocardia: heart predominantly in R hemithorax (Non-syndromic)
  

    

   Totally anomalous pulmonary venous connection (Non-syndromic)
  

    

   Hypoplastic left heart syndrome (Non-syndromic)
  

    

   ASD within oval fossa (secundum) (Non-syndromic)
  

    

   Right isomerism ('asplenia') (Non-syndromic)
  

    

   R aortic arch (Non-syndromic)
  

    

   Position or morphology of thoraco-abdominal organs abnormal (Non-syndromic)
  

    

   Pulmonary valvar stenosis - congenital (Non-syndromic)

[edit] Genes having syndromic CHDs

• ATRX - 1 association(s)
  
  
  
  

    

   ASD within oval fossa (secundum) (Syndromic)

• BCOR - 7 association(s)
  
  
  
  

    

   Patent arterial duct (PDA) (Syndromic)
  

    

   ASD (Syndromic)
  

    

   Aortic valvar stenosis - congenital (Syndromic)
  

    

   Pulmonary valvar stenosis - congenital (Syndromic)
  

    

   VSD (Syndromic)
  

    

   Mitral valvar prolapse (Syndromic)
  

    

   Double outlet RV (Syndromic)

• BRAF - 4 association(s)
  
  
  
  

    

   ASD (Syndromic)
  

    

   Pulmonary valvar stenosis - congenital (Syndromic)
  

    

   Tetralogy of Fallot (Syndromic)
  

    

   Supravalvar pulmonary trunk stenosis (Syndromic)

• CBP/CREBBP - 4 association(s)
  
  
  
  

    

   Patent arterial duct (PDA) (Syndromic)
  

    

   ASD within oval fossa (secundum) (Syndromic)
  

    

   Pulmonary valvar stenosis (Syndromic)
  

    

   VSD (Syndromic)

• CFC1/CRYPTIC - 8 association(s)
  
  
  
  

    

   AVSD: atrial & ventricular components (complete) (Non-syndromic)
  

    

   VSD (Non-syndromic)
  

    

   Double outlet RV (Syndromic)
  

    

   Double outlet RV (Non-syndromic)
  

    

   Tetralogy of Fallot (Non-syndromic)
  

    

   Interrupted aortic arch (Non-syndromic)
  

    

   Complete transposition of great arteries (IVS) (Non-syndromic)
  

    

   ASD (Non-syndromic)

• CHD7 - 8 association(s)
  
  
  
  

    

   Patent arterial duct (PDA) (Syndromic)
  

    

   Tetralogy of Fallot (Syndromic)
  

    

   Atrioventricular septal defect (Syndromic)
  

    

   RV hypoplasia (Syndromic)
  

    

   Hypoplastic left heart syndrome (Syndromic)
  

    

   Double outlet RV (Syndromic)
  

    

   ASD (Syndromic)
  

    

   VSD (Syndromic)

• COL2A1 - 1 association(s)
  
  
  
  

    

   Mitral valvar prolapse (Syndromic)

• CSDE1/NRAS - 2 association(s)
  
  
  
  

    

   Mitral valvar prolapse (Syndromic)
  

    

   Pulmonary valvar stenosis - congenital (Syndromic)

• EHMT1 - 1 association(s)
  
  
  
  

    

   Common arterial trunk (Syndromic)

• ELN - 11 association(s)
  
  
  
  

    

   Supravalvar pulmonary trunk stenosis (Non-syndromic)
  

    

   Peripheral pulmonary arterial stenoses - at/beyond hilar bifurcation (Non-syndromic)
  

    

   Pulmonary valvar stenosis - congenital (Non-syndromic)
  

    

   Supravalvar aortic stenosis (Non-syndromic)
  

    

   Supravalvar aortic stenosis (Syndromic)
  

    

   Subaortic stenosis (Syndromic)
  

    

   Aortic valvar stenosis - congenital (Syndromic)
  

    

   Peripheral pulmonary arterial stenoses - at/beyond hilar bifurcation (Syndromic)
  

    

   Mitral valvar prolapse (Syndromic)
  

    

   Bicuspid aortic valve (Syndromic)
  

    

   Aortic valvar stenosis - congenital (Non-syndromic)

• EVC - 1 association(s)
  
  
  
  

    

   Common atrium (virtual absence of atrial septum) (Syndromic)

• EVC2 - 5 association(s)
  
  
  
  

    

   VSD (Syndromic)
  

    

   Patent arterial duct (PDA) (Syndromic)
  

    

   Atrioventricular septal defect (Syndromic)
  

    

   AVSD: isolated atrial component (primum ASD) (Syndromic)
  

    

   ASD (Syndromic)

• FBN1 - 3 association(s)
  
  
  
  

    

   Mitral valvar prolapse (Syndromic)
  

    

   Ascending aorta dilation (Syndromic)
  

    

   Mitral regurgitation (Syndromic)

• FLNA - 5 association(s)
  
  
  
  

    

   Aortic valvar stenosis - congenital (Syndromic)
  

    

   Mitral atresia (Syndromic)
  

    

   Aortic regurgitation - congenital (Syndromic)
  

    

   Patent arterial duct (PDA) (Syndromic)
  

    

   Aortic coarctation (Syndromic)

• FOXC1 - 3 association(s)
  
  
  
  

    

   Aortic stenosis (Syndromic)
  

    

   Pulmonary valvar stenosis - congenital (Syndromic)
  

    

   ASD (Syndromic)

• FOXL2 - 1 association(s)
  
  
  
  

    

   VSD (Syndromic)

• G6PC3 - 2 association(s)
  
  
  
  

    

   Patent arterial duct (PDA) (Syndromic)
  

    

   ASD (Syndromic)

• GJA1 - 2 association(s)
  
  
  
  

    

   ASD (Syndromic)
  

    

   Hypoplastic left heart syndrome (Non-syndromic)

• GPC3 - 6 association(s)
  
  
  
  

    

   VSD (Syndromic)
  

    

   Patent foramen ovale (PFO) (Syndromic)
  

    

   Peripheral pulmonary arterial stenoses - at/beyond hilar bifurcation (Syndromic)
  

    

   ASD (Syndromic)
  

    

   Subaortic stenosis (Syndromic)
  

    

   Aortic stenosis (Syndromic)

• HOXA1 - 2 association(s)
  
  
  
  

    

   Tetralogy of Fallot (Syndromic)
  

    

   Muscular VSD (Syndromic)

• HRAS - 3 association(s)
  
  
  
  

    

   ASD (Syndromic)
  

    

   VSD (Syndromic)
  

    

   Pulmonary valvar stenosis - congenital (Syndromic)

• JAG1 - 10 association(s)
  
  
  
  

    

   Tetralogy of Fallot (Non-syndromic)
  

    

   VSD (Syndromic)
  

    

   Peripheral pulmonary arterial stenoses - at/beyond hilar bifurcation (Non-syndromic)
  

    

   Peripheral pulmonary arterial stenoses - at/beyond hilar bifurcation (Syndromic)
  

    

   Pulmonary atresia + VSD (including Fallot type) (Syndromic)
  

    

   Pulmonary valvar stenosis - congenital (Syndromic)
  

    

   Tetralogy of Fallot (Syndromic)
  

    

   Aortic coarctation (Syndromic)
  

    

   Aortic stenosis (Syndromic)
  

    

   Pulmonary atresia + intact ventricular septum (Syndromic)

• KRAS - 3 association(s)
  
  
  
  

    

   ASD (Syndromic)
  

    

   VSD (Syndromic)
  

    

   Pulmonary valvar stenosis - congenital (Syndromic)

• LBR - 1 association(s)
  
  
  
  

    

   VSD (Syndromic)

• MAP2K1/MEK1 - 4 association(s)
  
  
  
  

    

   Pulmonary valvar stenosis - congenital (Syndromic)
  

    

   Tetralogy of Fallot (Syndromic)
  

    

   Partially anomalous pulmonary venous connection(s) (Syndromic)
  

    

   ASD (Syndromic)

• MAP2K2/MEK2 - 3 association(s)
  
  
  
  

    

   Pulmonary valvar stenosis - congenital (Syndromic)
  

    

   Bicuspid aortic valve (Syndromic)
  

    

   ASD (Syndromic)

• MGP - 1 association(s)
  
  
  
  

    

   Peripheral pulmonary arterial stenoses - at/beyond hilar bifurcation (Syndromic)

• MID1 - 4 association(s)
  
  
  
  

    

   VSD (Syndromic)
  

    

   Patent foramen ovale (PFO) (Syndromic)
  

    

   Left SVC persisting to coronary sinus to right-sided atrium (Syndromic)
  

    

   Patent arterial duct (PDA) (Syndromic)

• MLL2 - 4 association(s)
  
  
  
  

    

   VSD (Syndromic)
  

    

   ASD (Syndromic)
  

    

   Bicuspid aortic valve (Syndromic)
  

    

   Aortic coarctation (Syndromic)

• NF1 - 2 association(s)
  
  
  
  

    

   Aortic coarctation (Syndromic)
  

    

   Pulmonary valvar stenosis - congenital (Syndromic)

• NOTCH2 - 3 association(s)
  
  
  
  

    

   Peripheral pulmonary arterial stenoses - at/beyond hilar bifurcation (Syndromic)
  

    

   Tetralogy of Fallot (Syndromic)
  

    

   Pulmonary valvar stenosis - congenital (Syndromic)

• NPHP3 - 3 association(s)
  
  
  
  

    

   ASD (Syndromic)
  

    

   Patent arterial duct (PDA) (Syndromic)
  

    

   Aortic stenosis (Syndromic)

• NSD1 - 4 association(s)
  
  
  
  

    

   Aortic coarctation (Syndromic)
  

    

   VSD (Syndromic)
  

    

   ASD (Syndromic)
  

    

   Patent arterial duct (PDA) (Syndromic)

• PTPN11 - 7 association(s)
  
  
  
  

    

   VSD (Syndromic)
  

    

   Peripheral pulmonary arterial stenoses - at/beyond hilar bifurcation (Syndromic)
  

    

   Aortic coarctation (Syndromic)
  

    

   Pulmonary valvar stenosis - congenital (Syndromic)
  

    

   Atrioventricular septal defect (Syndromic)
  

    

   ASD (Syndromic)
  

    

   Aortic valvar stenosis - congenital (Syndromic)

• RAF1 - 2 association(s)
  
  
  
  

    

   Pulmonary valvar stenosis - congenital (Syndromic)
  

    

   Hypertrophic cardiomyopathy (Syndromic)

• RAI1 - 1 association(s)
  
  
  
  

    

   ASD (Syndromic)

• RBM10 - 1 association(s)
  
  
  
  

    

   ASD (Syndromic)

• ROR2 - 1 association(s)
  
  
  
  

    

   VSD (Syndromic)

• SALL4 - 3 association(s)
  
  
  
  

    

   VSD (Syndromic)
  

    

   Tetralogy of Fallot (Syndromic)
  

    

   Patent foramen ovale (PFO) (Syndromic)

• SH3PXD2B - 3 association(s)
  
  
  
  

    

   Double outlet RV (Syndromic)
  

    

   Mitral valvar abnormality (Syndromic)
  

    

   VSD (Syndromic)

• SHOC2 - 4 association(s)
  
  
  
  

    

   Mitral valvar abnormality (Syndromic)
  

    

   ASD (Syndromic)
  

    

   Pulmonary valvar stenosis - congenital (Syndromic)
  

    

   VSD (Syndromic)

• SIP1/ZEB2/ZFHX1B - 5 association(s)
  
  
  
  

    

   Pulmonary valvar stenosis - congenital (Syndromic)
  

    

   Patent foramen ovale (PFO) (Syndromic)
  

    

   ASD (Syndromic)
  

    

   Patent arterial duct (PDA) (Syndromic)
  

    

   VSD (Syndromic)

• SLC2A10 - 1 association(s)
  
  
  
  

    

   Peripheral pulmonary arterial stenoses - at/beyond hilar bifurcation (Syndromic)

• SOS1 - 5 association(s)
  
  
  
  

    

   VSD (Syndromic)
  

    

   ASD (Syndromic)
  

    

   Aortic valvar stenosis - congenital (Syndromic)
  

    

   Pulmonary arterial stenosis (Syndromic)
  

    

   Pulmonary valvar stenosis - congenital (Syndromic)

• STRA6 - 1 association(s)
  
  
  
  

    

   Patent arterial duct (PDA) (Syndromic)

• TBX1 - 4 association(s)
  
  
  
  

    

   Pulmonary valvar stenosis - congenital (Syndromic)
  

    

   Tetralogy of Fallot (Syndromic)
  

    

   Interrupted aortic arch (Syndromic)
  

    

   R aortic arch (Non-syndromic)

• TBX3 - 2 association(s)
  
  
  
  

    

   Pulmonary valvar stenosis - congenital (Syndromic)
  

    

   VSD (Syndromic)

• TBX5 - 9 association(s)
  
  
  
  

    

   Atrioventricular septal defect (Syndromic)
  

    

   ASD (Syndromic)
  

    

   Double outlet RV (Syndromic)
  

    

   Common atrium (virtual absence of atrial septum) (Syndromic)
  

    

   ASD within oval fossa (secundum) (Syndromic)
  

    

   Aortic coarctation (Syndromic)
  

    

   Tetralogy of Fallot (Syndromic)
  

    

   VSD (Syndromic)
  

    

   Patent foramen ovale (PFO) (Syndromic)

• TFAP2B - 5 association(s)
  
  
  
  

    

   Bicuspid aortic valve (Syndromic)
  

    

   Patent arterial duct (PDA) (Syndromic)
  

    

   Patent arterial duct (PDA) (Non-syndromic)
  

    

   VSD (Syndromic)
  

    

   Aortic coarctation (Syndromic)

[edit] Both syndromic & non syndromic genes

• ACTC - 1 association(s)
  
  
  
  

    

   ASD within oval fossa (secundum) (Non-syndromic)

• ACVR1 - 1 association(s)
  
  
  
  

    

   AVSD: isolated atrial component (primum ASD) (Non-syndromic)

• ACVR2B - 6 association(s)
  
  
  
  

    

   Double outlet RV (Non-syndromic)
  

    

   Complete transposition of great arteries (IVS) (Non-syndromic)
  

    

   Pulmonary valvar stenosis - congenital (Non-syndromic)
  

    

   Dextrocardia: heart predominantly in R hemithorax (Non-syndromic)
  

    

   Position or morphology of thoraco-abdominal organs abnormal (Non-syndromic)
  

    

   AV and/or VA connections abnormal (Non-syndromic)

• ALDH1A2 - 1 association(s)
  
  
  
  

    

   Tetralogy of Fallot (Non-syndromic)

• ANKRD1 - 1 association(s)
  
  
  
  

    

   Totally anomalous pulmonary venous connection (Non-syndromic)

• ATRX - 1 association(s)
  
  
  
  

    

   ASD within oval fossa (secundum) (Syndromic)

• BCOR - 7 association(s)
  
  
  
  

    

   Patent arterial duct (PDA) (Syndromic)
  

    

   ASD (Syndromic)
  

    

   Aortic valvar stenosis - congenital (Syndromic)
  

    

   Pulmonary valvar stenosis - congenital (Syndromic)
  

    

   VSD (Syndromic)
  

    

   Mitral valvar prolapse (Syndromic)
  

    

   Double outlet RV (Syndromic)

• BRAF - 4 association(s)
  
  
  
  

    

   ASD (Syndromic)
  

    

   Pulmonary valvar stenosis - congenital (Syndromic)
  

    

   Tetralogy of Fallot (Syndromic)
  

    

   Supravalvar pulmonary trunk stenosis (Syndromic)

• CBP/CREBBP - 4 association(s)
  
  
  
  

    

   Patent arterial duct (PDA) (Syndromic)
  

    

   ASD within oval fossa (secundum) (Syndromic)
  

    

   Pulmonary valvar stenosis (Syndromic)
  

    

   VSD (Syndromic)

• CFC1/CRYPTIC - 8 association(s)
  
  
  
  

    

   AVSD: atrial & ventricular components (complete) (Non-syndromic)
  

    

   VSD (Non-syndromic)
  

    

   Double outlet RV (Syndromic)
  

    

   Double outlet RV (Non-syndromic)
  

    

   Tetralogy of Fallot (Non-syndromic)
  

    

   Interrupted aortic arch (Non-syndromic)
  

    

   Complete transposition of great arteries (IVS) (Non-syndromic)
  

    

   ASD (Non-syndromic)

• CHD7 - 8 association(s)
  
  
  
  

    

   Patent arterial duct (PDA) (Syndromic)
  

    

   Tetralogy of Fallot (Syndromic)
  

    

   Atrioventricular septal defect (Syndromic)
  

    

   RV hypoplasia (Syndromic)
  

    

   Hypoplastic left heart syndrome (Syndromic)
  

    

   Double outlet RV (Syndromic)
  

    

   ASD (Syndromic)
  

    

   VSD (Syndromic)

• CITED2 - 2 association(s)
  
  
  
  

    

   VSD (Non-syndromic)
  

    

   ASD (Non-syndromic)

• COL2A1 - 1 association(s)
  
  
  
  

    

   Mitral valvar prolapse (Syndromic)

• CRELD1 - 2 association(s)
  
  
  
  

    

   AVSD: atrial & ventricular components (complete) (Non-syndromic)
  

    

   AVSD: isolated atrial component (primum ASD) (Non-syndromic)

• CSDE1/NRAS - 2 association(s)
  
  
  
  

    

   Mitral valvar prolapse (Syndromic)
  

    

   Pulmonary valvar stenosis - congenital (Syndromic)

• EHMT1 - 1 association(s)
  
  
  
  

    

   Common arterial trunk (Syndromic)

• ELN - 11 association(s)
  
  
  
  

    

   Supravalvar pulmonary trunk stenosis (Non-syndromic)
  

    

   Peripheral pulmonary arterial stenoses - at/beyond hilar bifurcation (Non-syndromic)
  

    

   Pulmonary valvar stenosis - congenital (Non-syndromic)
  

    

   Supravalvar aortic stenosis (Non-syndromic)
  

    

   Supravalvar aortic stenosis (Syndromic)
  

    

   Subaortic stenosis (Syndromic)
  

    

   Aortic valvar stenosis - congenital (Syndromic)
  

    

   Peripheral pulmonary arterial stenoses - at/beyond hilar bifurcation (Syndromic)
  

    

   Mitral valvar prolapse (Syndromic)
  

    

   Bicuspid aortic valve (Syndromic)
  

    

   Aortic valvar stenosis - congenital (Non-syndromic)

• EVC - 1 association(s)
  
  
  
  

    

   Common atrium (virtual absence of atrial septum) (Syndromic)

• EVC2 - 5 association(s)
  
  
  
  

    

   VSD (Syndromic)
  

    

   Patent arterial duct (PDA) (Syndromic)
  

    

   Atrioventricular septal defect (Syndromic)
  

    

   AVSD: isolated atrial component (primum ASD) (Syndromic)
  

    

   ASD (Syndromic)

• FBN1 - 3 association(s)
  
  
  
  

    

   Mitral valvar prolapse (Syndromic)
  

    

   Ascending aorta dilation (Syndromic)
  

    

   Mitral regurgitation (Syndromic)

• FLNA - 5 association(s)
  
  
  
  

    

   Aortic valvar stenosis - congenital (Syndromic)
  

    

   Mitral atresia (Syndromic)
  

    

   Aortic regurgitation - congenital (Syndromic)
  

    

   Patent arterial duct (PDA) (Syndromic)
  

    

   Aortic coarctation (Syndromic)

• FOG2/ZFPM2 - 3 association(s)
  
  
  
  

    

   Tetralogy of Fallot (Non-syndromic)
  

    

   Double outlet RV (Non-syndromic)
  

    

   Tricuspid atresia (Non-syndromic)

• FOXC1 - 3 association(s)
  
  
  
  

    

   Aortic stenosis (Syndromic)
  

    

   Pulmonary valvar stenosis - congenital (Syndromic)
  

    

   ASD (Syndromic)

• FOXH1 - 2 association(s)
  
  
  
  

    

   Complete transposition of great arteries (IVS) (Non-syndromic)
  

    

   Tetralogy of Fallot (Non-syndromic)

• FOXL2 - 1 association(s)
  
  
  
  

    

   VSD (Syndromic)

• G6PC3 - 2 association(s)
  
  
  
  

    

   Patent arterial duct (PDA) (Syndromic)
  

    

   ASD (Syndromic)

• GATA4 - 6 association(s)
  
  
  
  

    

   ASD (Non-syndromic)
  

    

   Atrioventricular septal defect (Non-syndromic)
  

    

   Pulmonary valvar stenosis - congenital (Non-syndromic)
  

    

   Partially anomalous pulmonary venous connection(s) (Non-syndromic)
  

    

   Tetralogy of Fallot (Non-syndromic)
  

    

   VSD (Non-syndromic)

• GATA6 - 6 association(s)
  
  
  
  

    

   AVSD with ventricular imbalance (Non-syndromic)
  

    

   Common arterial trunk (Non-syndromic)
  

    

   ASD (Non-syndromic)
  

    

   Tetralogy of Fallot (Non-syndromic)
  

    

   Pulmonary valvar stenosis - congenital (Non-syndromic)
  

    

   Patent arterial duct (PDA) (Non-syndromic)

• GDF1 - 5 association(s)
  
  
  
  

    

   Complete transposition of great arteries (IVS) (Non-syndromic)
  

    

   Right isomerism ('asplenia') (Non-syndromic)
  

    

   Double outlet RV (Non-syndromic)
  

    

   AV and/or VA connections abnormal (Non-syndromic)
  

    

   Tetralogy of Fallot (Non-syndromic)

• GJA1 - 2 association(s)
  
  
  
  

    

   ASD (Syndromic)
  

    

   Hypoplastic left heart syndrome (Non-syndromic)

• GPC3 - 6 association(s)
  
  
  
  

    

   VSD (Syndromic)
  

    

   Patent foramen ovale (PFO) (Syndromic)
  

    

   Peripheral pulmonary arterial stenoses - at/beyond hilar bifurcation (Syndromic)
  

    

   ASD (Syndromic)
  

    

   Subaortic stenosis (Syndromic)
  

    

   Aortic stenosis (Syndromic)

• HAND2 - 1 association(s)
  
  
  
  

    

   Tetralogy of Fallot (Non-syndromic)

• HEY2 - 1 association(s)
  
  
  
  

    

   Tricuspid atresia (Non-syndromic)

• HOXA1 - 2 association(s)
  
  
  
  

    

   Tetralogy of Fallot (Syndromic)
  

    

   Muscular VSD (Syndromic)

• HRAS - 3 association(s)
  
  
  
  

    

   ASD (Syndromic)
  

    

   VSD (Syndromic)
  

    

   Pulmonary valvar stenosis - congenital (Syndromic)

• IRX4 - 1 association(s)
  
  
  
  

    

   VSD (Non-syndromic)

• JAG1 - 10 association(s)
  
  
  
  

    

   Tetralogy of Fallot (Non-syndromic)
  

    

   VSD (Syndromic)
  

    

   Peripheral pulmonary arterial stenoses - at/beyond hilar bifurcation (Non-syndromic)
  

    

   Peripheral pulmonary arterial stenoses - at/beyond hilar bifurcation (Syndromic)
  

    

   Pulmonary atresia + VSD (including Fallot type) (Syndromic)
  

    

   Pulmonary valvar stenosis - congenital (Syndromic)
  

    

   Tetralogy of Fallot (Syndromic)
  

    

   Aortic coarctation (Syndromic)
  

    

   Aortic stenosis (Syndromic)
  

    

   Pulmonary atresia + intact ventricular septum (Syndromic)

• KRAS - 3 association(s)
  
  
  
  

    

   ASD (Syndromic)
  

    

   VSD (Syndromic)
  

    

   Pulmonary valvar stenosis - congenital (Syndromic)

• LBR - 1 association(s)
  
  
  
  

    

   VSD (Syndromic)

• LEFTY2 - 7 association(s)
  
  
  
  

    

   Aortic coarctation (Non-syndromic)
  

    

   Position or morphology of thoraco-abdominal organs abnormal (Non-syndromic)
  

    

   AVSD: atrial & ventricular components (complete) (Non-syndromic)
  

    

   Left SVC persisting to coronary sinus to right-sided atrium (Non-syndromic)
  

    

   Interrupted aortic arch (Non-syndromic)
  

    

   Inferior caval vein (IVC) abnormality (Non-syndromic)
  

    

   Congenitally corrected transposition of great arteries (Non-syndromic)

• MAP2K1/MEK1 - 4 association(s)
  
  
  
  

    

   Pulmonary valvar stenosis - congenital (Syndromic)
  

    

   Tetralogy of Fallot (Syndromic)
  

    

   Partially anomalous pulmonary venous connection(s) (Syndromic)
  

    

   ASD (Syndromic)

• MAP2K2/MEK2 - 3 association(s)
  
  
  
  

    

   Pulmonary valvar stenosis - congenital (Syndromic)
  

    

   Bicuspid aortic valve (Syndromic)
  

    

   ASD (Syndromic)

• MAP3K7IP2 - 1 association(s)
  
  
  
  

    

   LV outflow tract obstruction (Non-syndromic)

• MGP - 1 association(s)
  
  
  
  

    

   Peripheral pulmonary arterial stenoses - at/beyond hilar bifurcation (Syndromic)

• MID1 - 4 association(s)
  
  
  
  

    

   VSD (Syndromic)
  

    

   Patent foramen ovale (PFO) (Syndromic)
  

    

   Left SVC persisting to coronary sinus to right-sided atrium (Syndromic)
  

    

   Patent arterial duct (PDA) (Syndromic)

• MLL2 - 4 association(s)
  
  
  
  

    

   VSD (Syndromic)
  

    

   ASD (Syndromic)
  

    

   Bicuspid aortic valve (Syndromic)
  

    

   Aortic coarctation (Syndromic)

• MYH11 - 2 association(s)
  
  
  
  

    

   Aortic sinus of Valsalva aneurysm (Non-syndromic)
  

    

   Patent arterial duct (PDA) (Non-syndromic)

• MYH6 - 5 association(s)
  
  
  
  

    

   Aortic valvar stenosis - congenital (Non-syndromic)
  

    

   Tricuspid atresia (Non-syndromic)
  

    

   ASD within oval fossa (secundum) (Non-syndromic)
  

    

   Complete transposition of great arteries (IVS) (Non-syndromic)
  

    

   Patent foramen ovale (PFO) (Non-syndromic)

• MYH7 - 2 association(s)
  
  
  
  

    

   Ebstein's malformation of tricuspid valve (Non-syndromic)
  

    

   ASD (Non-syndromic)

• NF1 - 2 association(s)
  
  
  
  

    

   Aortic coarctation (Syndromic)
  

    

   Pulmonary valvar stenosis - congenital (Syndromic)

• NKX2-5/NKX2.5 - 11 association(s)
  
  
  
  

    

   Aortic coarctation (Non-syndromic)
  

    

   Interrupted aortic arch (Non-syndromic)
  

    

   Double outlet RV (Non-syndromic)
  

    

   Sinus venosus ASD (Non-syndromic)
  

    

   Complete transposition of great arteries (IVS) (Non-syndromic)
  

    

   Common arterial trunk (Non-syndromic)
  

    

   Hypoplastic left heart syndrome (Non-syndromic)
  

    

   ASD (Non-syndromic)
  

    

   VSD (Non-syndromic)
  

    

   Tetralogy of Fallot (Non-syndromic)
  

    

   Multiple VSDs (Non-syndromic)

• NKX2-6 - 1 association(s)
  
  
  
  

    

   Common arterial trunk (Non-syndromic)

• NODAL - 13 association(s)
  
  
  
  

    

   Position or morphology of thoraco-abdominal organs abnormal (Non-syndromic)
  

    

   Ventricular imbalance: dominant LV + hypoplastic RV (Non-syndromic)
  

    

   Pulmonary atresia (Non-syndromic)
  

    

   Complete transposition of great arteries (IVS) (Non-syndromic)
  

    

   Tetralogy of Fallot (Non-syndromic)
  

    

   Double outlet RV (Non-syndromic)
  

    

   Dextrocardia: heart predominantly in R hemithorax (Non-syndromic)
  

    

   Atrioventricular septal defect (Non-syndromic)
  

    

   Left SVC persisting to coronary sinus to right-sided atrium (Non-syndromic)
  

    

   Inferior caval vein (IVC) abnormality (Non-syndromic)
  

    

   Totally anomalous pulmonary venous connection (Non-syndromic)
  

    

   Ventricular imbalance: dominant RV + hypoplastic LV (Non-syndromic)
  

    

   AV and/or VA connections abnormal (Non-syndromic)

• NOTCH1 - 4 association(s)
  
  
  
  

    

   Aortic coarctation (Non-syndromic)
  

    

   Hypoplastic left heart syndrome (Non-syndromic)
  

    

   Bicuspid aortic valve (Non-syndromic)
  

    

   Aortic valvar stenosis - congenital (Non-syndromic)

• NOTCH2 - 3 association(s)
  
  
  
  

    

   Peripheral pulmonary arterial stenoses - at/beyond hilar bifurcation (Syndromic)
  

    

   Tetralogy of Fallot (Syndromic)
  

    

   Pulmonary valvar stenosis - congenital (Syndromic)

• NPHP3 - 3 association(s)
  
  
  
  

    

   ASD (Syndromic)
  

    

   Patent arterial duct (PDA) (Syndromic)
  

    

   Aortic stenosis (Syndromic)

• NSD1 - 4 association(s)
  
  
  
  

    

   Aortic coarctation (Syndromic)
  

    

   VSD (Syndromic)
  

    

   ASD (Syndromic)
  

    

   Patent arterial duct (PDA) (Syndromic)

• PDGFRA - 1 association(s)
  
  
  
  

    

   Totally anomalous pulmonary venous connection (Non-syndromic)

• PTPN11 - 7 association(s)
  
  
  
  

    

   VSD (Syndromic)
  

    

   Peripheral pulmonary arterial stenoses - at/beyond hilar bifurcation (Syndromic)
  

    

   Aortic coarctation (Syndromic)
  

    

   Pulmonary valvar stenosis - congenital (Syndromic)
  

    

   Atrioventricular septal defect (Syndromic)
  

    

   ASD (Syndromic)
  

    

   Aortic valvar stenosis - congenital (Syndromic)

• RAF1 - 2 association(s)
  
  
  
  

    

   Pulmonary valvar stenosis - congenital (Syndromic)
  

    

   Hypertrophic cardiomyopathy (Syndromic)

• RAI1 - 1 association(s)
  
  
  
  

    

   ASD (Syndromic)

• RBM10 - 1 association(s)
  
  
  
  

    

   ASD (Syndromic)

• ROR2 - 1 association(s)
  
  
  
  

    

   VSD (Syndromic)

• SALL4 - 3 association(s)
  
  
  
  

    

   VSD (Syndromic)
  

    

   Tetralogy of Fallot (Syndromic)
  

    

   Patent foramen ovale (PFO) (Syndromic)

• SH3PXD2B - 3 association(s)
  
  
  
  

    

   Double outlet RV (Syndromic)
  

    

   Mitral valvar abnormality (Syndromic)
  

    

   VSD (Syndromic)

• SHOC2 - 4 association(s)
  
  
  
  

    

   Mitral valvar abnormality (Syndromic)
  

    

   ASD (Syndromic)
  

    

   Pulmonary valvar stenosis - congenital (Syndromic)
  

    

   VSD (Syndromic)

• SIP1/ZEB2/ZFHX1B - 5 association(s)
  
  
  
  

    

   Pulmonary valvar stenosis - congenital (Syndromic)
  

    

   Patent foramen ovale (PFO) (Syndromic)
  

    

   ASD (Syndromic)
  

    

   Patent arterial duct (PDA) (Syndromic)
  

    

   VSD (Syndromic)

• SLC2A10 - 1 association(s)
  
  
  
  

    

   Peripheral pulmonary arterial stenoses - at/beyond hilar bifurcation (Syndromic)

• SOS1 - 5 association(s)
  
  
  
  

    

   VSD (Syndromic)
  

    

   ASD (Syndromic)
  

    

   Aortic valvar stenosis - congenital (Syndromic)
  

    

   Pulmonary arterial stenosis (Syndromic)
  

    

   Pulmonary valvar stenosis - congenital (Syndromic)

• STRA6 - 1 association(s)
  
  
  
  

    

   Patent arterial duct (PDA) (Syndromic)

• TBX1 - 4 association(s)
  
  
  
  

    

   Pulmonary valvar stenosis - congenital (Syndromic)
  

    

   Tetralogy of Fallot (Syndromic)
  

    

   Interrupted aortic arch (Syndromic)
  

    

   R aortic arch (Non-syndromic)

• TBX20 - 3 association(s)
  
  
  
  

    

   Mitral valvar stenosis - congenital (Non-syndromic)
  

    

   ASD (Non-syndromic)
  

    

   VSD (Non-syndromic)

• TBX3 - 2 association(s)
  
  
  
  

    

   Pulmonary valvar stenosis - congenital (Syndromic)
  

    

   VSD (Syndromic)

• TBX5 - 9 association(s)
  
  
  
  

    

   Atrioventricular septal defect (Syndromic)
  

    

   ASD (Syndromic)
  

    

   Double outlet RV (Syndromic)
  

    

   Common atrium (virtual absence of atrial septum) (Syndromic)
  

    

   ASD within oval fossa (secundum) (Syndromic)
  

    

   Aortic coarctation (Syndromic)
  

    

   Tetralogy of Fallot (Syndromic)
  

    

   VSD (Syndromic)
  

    

   Patent foramen ovale (PFO) (Syndromic)

• TDGF1 - 2 association(s)
  
  
  
  

    

   Tetralogy of Fallot (Non-syndromic)
  

    

   VSD (Non-syndromic)

• TFAP2B - 5 association(s)
  
  
  
  

    

   Bicuspid aortic valve (Syndromic)
  

    

   Patent arterial duct (PDA) (Syndromic)
  

    

   Patent arterial duct (PDA) (Non-syndromic)
  

    

   VSD (Syndromic)
  

    

   Aortic coarctation (Syndromic)

• THRAP2 - 1 association(s)
  
  
  
  

    

   Complete transposition of great arteries (IVS) (Non-syndromic)

• VEGF - 1 association(s)
  
  
  
  

    

   Aortic coarctation (Non-syndromic)

• ZIC3 - 12 association(s)
  
  
  
  

    

   Double outlet RV (Non-syndromic)
  

    

   Multiple VSDs (Non-syndromic)
  

    

   VSD (Non-syndromic)
  

    

   Complete transposition of great arteries (IVS) (Non-syndromic)
  

    

   Dextrocardia: heart predominantly in R hemithorax (Non-syndromic)
  

    

   Totally anomalous pulmonary venous connection (Non-syndromic)
  

    

   Hypoplastic left heart syndrome (Non-syndromic)
  

    

   ASD within oval fossa (secundum) (Non-syndromic)
  

    

   Right isomerism ('asplenia') (Non-syndromic)
  

    

   R aortic arch (Non-syndromic)
  

    

   Position or morphology of thoraco-abdominal organs abnormal (Non-syndromic)
  

    

   Pulmonary valvar stenosis - congenital (Non-syndromic)

[edit] Candidate genes

Note: A gene is considered as a CHD candidate gene, when it has a dedicated page but is not already associated to any heart defect.

• AATK

• ACTG1

• AKT1

• AP1B1

• ARID4A

• AXIN1

• BMP4

• CCDC40

• CCN1

• CSNK1D

• CSRP1

• DLG7

• DVL1

• DVL1L1

• EP300

• ETS1

• EWSR1

• FBN2

• FGF10

• FGF8

• FOXK2

• GJA9

• HAND1

• HES4

• HMGB2

• ID2

• IGFBP4

• ISL1

• ISLET1

• JAM3

• JAZF1

• KREMEN1

• LTBP3

• MAFG

• MTHFR

• OTX2

• PCSK5

• PITX2

• PLAGL1

• PPP3CA

• PROX1

• RAI2

• RBBP7

• SESN1

• SKI

• SMAD6

• TBX6

• TCF21

• THOC5

• TP73

• TWIST1

• VEGFC

[edit] Predicted candidate genes

Note: Four prioritization tools have been used to predict novel CHD candidate genes (Endeavour, GeneDistiller, Pinta, and Candid) (Capdevila et al., 2012). In this section, the genes are ordered by their final rank. Already known genes and candidates (from the above sections) have been removed.

• BMPR1A (1)

• MYBPC3 (3)

• SCN5A (4)

• LMNA (5)

• TGFBR2 (6)

• TGFBR1 (7)

• FGFR1 (9)

• NOTCH3 (10)

• TGFB1 (11)

• TNNT2 (14)

• CASQ2 (16)

• PDGFRB (17)

• CTNNB1 (18)

• PTEN (19)

• COL1A1 (21)

• HNF1A (22)

• LAMC1 (24)

• FGFR2 (26)

• GLI3 (27)

• ACTA1 (29)

• TNNC1 (30)

• PSEN1 (31)

• MITF (32)

• CSRP3 (33)

• AKT2 (34)

• ACVRL1 (35)

• DES (36)

• GJA5 (37)

• HSPG2 (38)

• KIT (39)

• ACVR2A (40)

• ITGB1 (41)

• MYL2 (43)

• TGFB2 (44)

• ACVR1B (45)

• EFEMP2 (46)

• TNNI3 (47)

• FHL2 (48)

• MYL7 (49)

• ACTN2 (50)

• PAX3 (51)

• EGFR (52)

• HOXB1 (53)

• SP1 (54)

• FLT4 (55)

• ILK (56)

• NOS3 (57)

• NPPA (59)

• TTN (60)

• TFAP2A (61)

• KDR (63)

• TP53 (64)

• SHH (65)

• LMX1B (67)

• MET (68)

• MYOZ2 (69)

• RELA (71)

• GLI2 (72)

• GTF2I (73)

• MYH10 (74)

• MYL3 (75)

• INHBA (76)

• NRP1 (77)

• FBLN1 (78)

• PDGFC (79)

• GTF2IRD1 (80)

• CAV3 (81)

• DLL1 (82)

• LTBP1 (83)

• MYC (84)

• RET (85)

• ITGB3 (86)

• MMP2 (87)

• FGFR3 (88)

• CDX2 (89)

• CRIP2 (90)

• ERBB2 (91)

• SMAD3 (92)

• RB1 (93)

• ABL1 (94)

• IGF1R (95)

• TNFRSF1A (96)

• SLC25A4 (97)

• BMP2 (98)

• FLNC (99)

• NFKB1 (100)

• TEK (101)

• NID2 (102)

• NRP2 (103)

• SMAD4 (104)

• ACTB (105)

• FOXO1 (106)

• INHBC (107)

• GDNF (108)

• SMAD2 (109)

• ITGB4 (111)

• CAV1 (112)

• FABP3 (113)

• ENG (115)

• THBS1 (116)

• MYH9 (117)

• EPHB2 (118)

• PRKACA (119)

• FN1 (120)

• INSR (121)

• IRS1 (122)

• GLB1 (123)

• PPARG (124)

• NKX2-1 (125)

• TGFB3 (127)

• VDR (128)

• EDNRA (129)

• HSPB1 (130)

• F2R (131)

• PLAT (132)

• GDF5 (133)

• TBX2 (134)

• FLT1 (135)

• PSEN2 (136)

• THBS4 (137)

• INPP5D (138)

• JUN (139)

• APC (140)

• ITGAV (141)

• SGCA (142)

• RYR2 (143)

• SOX2 (144)

• BMP7 (145)

• ACAN (146)

• TNFRSF11A (147)

• HIF1A (148)

• PTP4A3 (149)

• CRYAB (150)

• LAMA2 (151)

• GDF11 (152)

• HSPB8 (153)

• HNF4A (155)

• GATA2 (156)

• PDX1 (157)

• FLI1 (158)

• AR (159)

• YY1 (160)

• TFAP2C (162)

• TCAP (163)

• WNT11 (164)

• MECOM (165)

• THRB (166)

• MAPK14 (167)

• LEFTY1 (168)

• ATP2A2 (169)

• SRF (170)

• STAT3 (171)

• CDK4 (173)

• BMP10 (174)

• COL1A2 (175)

• TGIF1 (176)

• TPM1 (178)

• TEAD1 (180)

• E2F1 (182)

• RARB (183)

• APAF1 (184)

• TNR (185)

• MSX1 (186)

• BMP6 (187)

• ESR2 (188)

• EGR1 (189)

• TCF3 (190)

• RARG (191)

• EPHB4 (192)

• PTK2 (194)

• LAMA5 (195)

• PRRX1 (196)

• LHX3 (197)

• IKBKB (198)

• BMPR2 (199)

• MYOM1 (200)